Yes, you can do that quite easily, especially in the latest version of MetaMod (make sure you have the latest one) that has specific K2 support.

The PHP used could be this:

$k2 = JomGenius("k2");
if (! $k2->check("pagetype = item.view")) return; // do nothing if it's not an item page
$item_id = $k2->info("item_id");
if ($item_id == 10) return 100;
if ($item_id == 11) return 101;
if ($item_id == 12) return 102;
// add more as appropriate. the 2st number is the item id, and
// the 2nd number is the module to return for that item.